Hydrochloric Acid → 4,4-difluoro-1,4'-bipiperidine

HRID 821394Notes

Reaction equation

HRID 821394 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][C:17]([F:20])([F:21])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1.[CH3:25][OH:26].[ClH:24].[H:22][H:23]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][C:17]([F:20])([F:21])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 685813714,4-Difluoro-1′-(phenylmethyl)-1,4′-bipiperidineHCID 178418361HCID 178418361, compound

Product 1

HCID 534187744,4-difluoro-1,4'-bipiperidine

Sources & evidence

ORD record
ord-32e590f9b7434280833f7eb216a65d0b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…