Potassium Cation → tert-butyl 5-(2-(3-((1-methyl-1H-imidazol-2-yl)methoxy)-phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

HRID 821430Notes

Reaction equation

HRID 821430 reaction equation
[Cl:35][CH2:36][c:37]1[n:38]([CH3:42])[cH:39][cH:40][n:41]1.[Cl:54][CH2:55][Cl:56].[K+:43].[K+:44].[O-:45][C:46]([O-:47])=[O:48].[O:49]=[CH:50][N:51]([CH3:52])[CH3:53].[OH:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([NH:18][c:19]3[cH:20][c:21]4[cH:22][n:23][n:24]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[c:25]4[cH:26][cH:27]3)[n:17]2)[cH:5][cH:6][cH:7]1>>[O:1]([c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([NH:18][c:19]3[cH:20][c:21]4[cH:22][n:23][n:24]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[c:25]4[cH:26][cH:27]3)[n:17]2)[cH:5][cH:6][cH:7]1)[CH2:36][c:37]1[n:38]([CH3:42])[cH:39][cH:40][n:41]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 7365362-(chloromethyl)-1-methyl-1H-imidazoleHCID 569494541H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]amino]-, 1,1-dimethylethyl ester

Product 1

HCID 59361949tert-butyl 5-(2-(3-((1-methyl-1H-imidazol-2-yl)methoxy)-phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Sources & evidence

ORD record
ord-757b088c59e44349aa3ad54b22cde900
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…