Dimethyl Sulfoxide → 1-Boc-2-Formylpyrrolidine

HRID 821449Notes

Reaction equation

HRID 821449 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:10][OH:11])[CH2:12][CH2:13][CH2:14]1.[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[CH3:40][S:41]([CH3:42])=[O:43].[CH3:44][CH2:45][O:46][CH2:47][CH3:48].[Cl:37][CH2:38][Cl:39].[Na+:36].[O-:32][C:33]([OH:34])=[O:35].[S:28](=[O:29])(=[O:30])=[O:31].[n:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:10]=[O:11])[CH2:12][CH2:13][CH2:14]1

Participants

10

Reactant 9

HCID 679Dimethyl SulfoxideHCID 769Bicarbonate IonHCID 923Sodium ionHCID 1049PyridineHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24682Sulfur trioxideHCID 550865tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Product 1

HCID 42278151-Boc-2-Formylpyrrolidine

Sources & evidence

ORD record
ord-f1a0f9cfb3f94c99a6f67b8151c40ebe
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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