HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide → (5-Bromopyridin-3-yl)[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide | HCID 18472269 | — |
| Reactant | 7-(1-((Tert-butyldimethylsilyl)oxy)-2-methylpropan-2-YL)-2-chloro-5-iodo-7H-pyrrolo[2,3-D]pyrimidine | HCID 86672084 | — |
| Product | (5-Bromopyridin-3-yl)[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone | HCID 86672086 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 28 using 7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (see Preparation 44) and 5-bromo-N-methoxy-N-methylnicotinamide to afford the title compound as a yellow solid in 42% yield, 1.40 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846698B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-826b2e4f2b0f40c99d31fffe50b9f7b2 |
| Source note | uspto-grants-2014_09 |