5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide → (5-Bromopyridin-3-yl)(7-tert-butyl-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

HRID 82169Notes

Reaction equation

HRID 82169 reaction equation
[C:1]([N:5]1[C:9]2[N:10]=[C:11]([Cl:14])[N:12]=[CH:13][C:8]=2[C:7](I)=[CH:6]1)([CH3:4])([CH3:3])[CH3:2].[Br:16][C:17]1[CH:18]=[N:19][CH:20]=[C:21]([CH:28]=1)[C:22](N(OC)C)=[O:23]>>[Br:16][C:17]1[CH:28]=[C:21]([C:22]([C:7]2[C:8]3[CH:13]=[N:12][C:11]([Cl:14])=[N:10][C:9]=3[N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:6]=2)=[O:23])[CH:20]=[N:19][CH:18]=1

Participants

3

Reactant 2

HCID 184722695-Bromo-N-methoxy-N-methylpyridine-3-carboxamideHCID 86672095HCID 86672095, compound

Product 1

HCID 86672094(5-Bromopyridin-3-yl)(7-tert-butyl-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

Procedure

The title compound was prepared according to the method described for Preparation 28 using 7-tert-butyl-2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (see Preparation 63) and 5-bromo-N-methoxy-N-methylnicotinamide to afford the title compound as a brown oil in 36% yield, 2.1 g.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-c3181a4f09654b04a5470105e1c69a8e
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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