反应详情

温度

25 °C

Trifluoroacetic acid (10 mL) was added to tert-butyl[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetate (1.3 g, 5.2 mmol) (see Preparation 84) in dry DCM (10 mL) and the mixture was stirred for 18 hours at 25° C. Then the mixture was evaporated in vacuo and the residue was purified by trituration with diethyl ether:pentane (1:9, 2 mL) to afford the title compound as a white solid in 79% yield, 800 mg.

1. customThen the mixture was evaporated in vacuo
2. customthe residue was purified by trituration with diethyl ether:pentane (1:9, 2 mL)