Hydrochloric Acid → 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

HRID 821805Notes

Reaction equation

HRID 821805 reaction equation
[CH3:1][C:2]([CH2:3][C:4]1([C:7]([F:8])([F:9])[F:10])[O:5][CH2:6]1)([CH3:11])[c:12]1[cH:13][cH:14][cH:15][c:16]2[c:20]1[O:19][CH2:18][CH2:17]2.[ClH:21].[c:22]1(-[n:28]2[n:29][cH:30][c:31]3[c:32]([NH2:37])[cH:33][cH:34][cH:35][c:36]23)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[CH3:1][C:2]([CH2:3][C:4]([OH:5])([CH2:6][NH:37][c:32]1[c:31]2[cH:30][n:29][n:28](-[c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[c:36]2[cH:35][cH:34][cH:33]1)[C:7]([F:8])([F:9])[F:10])([CH3:11])[c:12]1[cH:13][cH:14][cH:15][c:16]2[c:20]1[O:19][CH2:18][CH2:17]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 249380571-phenyl-1H-indazol-4-amineHCID 577755187-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran

Product 1

HCID 576159414-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Sources & evidence

ORD record
ord-4c7e4079d1c24633b2d6d40ccaf69760
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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