HCID 70817590, compound → {7-[2-{[tert-Butyl(dimethyl)silyl]oxy}-1-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-methylethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}{5-[(diphenylmethylene)amino]pyridin-3-yl}methanone

HRID 82185Notes

Reaction equation

HRID 82185 reaction equation
[Si:1]([O:8][CH2:9][C:10]([N:21]1[C:25]2[N:26]=[CH:27][N:28]=[CH:29][C:24]=2[C:23](I)=[CH:22]1)([CH2:12][O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[CH3:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:31]1([C:37](=[N:44][C:45]2[CH:46]=[N:47][CH:48]=[C:49]([CH:56]=2)[C:50](N(OC)C)=[O:51])[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[Si:1]([O:8][CH2:9][C:10]([N:21]1[C:25]2[N:26]=[CH:27][N:28]=[CH:29][C:24]=2[C:23]([C:50]([C:49]2[CH:48]=[N:47][CH:46]=[C:45]([N:44]=[C:37]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH:56]=2)=[O:51])=[CH:22]1)([CH2:12][O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[CH3:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 70817590HCID 70817590, compoundHCID 866720805-((Diphenylmethylene)amino)-N-methoxy-N-methylnicotinamide

Product 1

HCID 86672103{7-[2-{[tert-Butyl(dimethyl)silyl]oxy}-1-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-methylethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}{5-[(diphenylmethylene)amino]pyridin-3-yl}methanone

Procedure

The title compound was prepared according to the method described for Preparation 28 using 7-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-methylethyl]-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (Preparation 114) and 5-[(diphenylmethylene)amino]-N-methoxy-N-methylnicotinamide (Preparation 23) to afford the title compound as a yellow foam in 69% yield, 1.76 g.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-1bae474f8cab4773bb9858a711598b1c
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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