反应详情

温度

90 °C

To a solution of imidazo[1,2-a]pyridin-7-yl-acetic acid ethyl ester (180 mg, 0.65 mmol) (Preparation 130) in dioxane (4 mL) at 0° C. was added 2 N aqueous sodium hydroxide solution (4 mL). Then reaction mixture was heated at 90° C. for 6 hours. After cooling to 0° C., the mixture was acidified to pH 4 with 2 N aqueous hydrochoric acid and extracted with 20% isopropanol in dichoromethane (8×10 mL). The combined organics were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound as an off-white solid in 70% yield, 80 mg.

1. customThen reaction mixture
2. temperatureAfter cooling to 0° C.
3. extractionextracted with 20% isopropanol in dichoromethane (8×10 mL)
4. dry with materialThe combined organics were dried over sodium sulfate
5. concentrationconcentrated under reduced pressure