3-(Trifluoromethyl)benzeneacetic acid → N-[5-({7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-[3-(trifluoromethyl)phenyl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	3-(Trifluoromethyl)benzeneacetic acid	HCID 67695	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	(5-Aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone	HCID 70817116	—
Product	N-[5-({7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-[3-(trifluoromethyl)phenyl]acetamide	HCID 70817388	—

Reaction Steps

Prepared according to the method described above for Example 1, using (5-aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (Preparation 36) and 3-trifluoromethylphenylacetic acid with DIPEA as base.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846698B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-dba49e6d484a4091a9238d8fc72c5dda
Source note	uspto-grants-2014_09