HRID82203

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67695

[3-(Trifluoromethyl)phenyl]acetic acid

C9H7F3O2

HCID81531

Diisopropylethylamine

C8H19N

结构：C[C@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21

HCID70817116

未命名化合物

PRODUCTS

生成物

结构：C[C@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21

HCID70817388

未命名化合物

PROCEDURE

实验过程

Prepared according to the method described above for Example 1, using (5-aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (Preparation 36) and 3-trifluoromethylphenylacetic acid with DIPEA as base.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dba49e6d484a4091a9238d8fc72c5dda
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846698B2
来源说明: uspto-grants-2014_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([C@H:19]([CH3:28])[CH2:20][O:21][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][O:23]3)[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[F:29][C:30]([F:42])([F:41])[C:31]1[CH:32]=[C:33]([CH2:37][C:38](O)=[O:39])[CH:34]=[CH:35][CH:36]=1.CCN(C(C)C)C(C)C>>[CH3:28][C@@H:19]([N:12]1[C:13]2[N:14]=[CH:15][N:16]=[CH:17][C:18]=2[C:10]([C:8]([C:4]2[CH:3]=[C:2]([NH:1][C:38](=[O:39])[CH2:37][C:33]3[CH:34]=[CH:35][CH:36]=[C:31]([C:30]([F:41])([F:29])[F:42])[CH:32]=3)[CH:7]=[N:6][CH:5]=2)=[O:9])=[CH:11]1)[CH2:20][O:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][O:23]1