Hydrochloric Acid → [1-[(2-amino-2,3-dihydro-1H-inden-5-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]methanol

HRID 822069Notes

Reaction equation

HRID 822069 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[NH:10][CH:11]1[CH2:12][c:13]2[cH:14][cH:15][c:16]([CH2:20][n:21]3[n:22][c:23]([C:28]([F:29])([F:30])[F:31])[c:24]([CH2:26][OH:27])[cH:25]3)[cH:17][c:18]2[CH2:19]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:32]1.[CH3:33][CH2:34][OH:35].[Cl:39][CH2:40][Cl:41].[ClH:36].[H:37][H:38].[OH-:42].[OH-:44].[Pd+2:43]>>[NH2:10][CH:11]1[CH2:12][c:13]2[cH:14][cH:15][c:16]([CH2:20][n:21]3[n:22][c:23]([C:28]([F:29])([F:30])[F:31])[c:24]([CH2:26][OH:27])[cH:25]3)[cH:17][c:18]2[CH2:19]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 702EthanolHCID 961Hydroxide2×HCID 6344DichloromethaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 178418361HCID 178418361, compoundHCID 178521719HCID 178521719, compound

Product 1

HCID 67088047[1-[(2-amino-2,3-dihydro-1H-inden-5-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]methanol

Sources & evidence

ORD record
ord-cb5f2fac117b48bbb007543b9bdad708
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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