Methylamine → (7-Isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(5-(methylamino)pyridin-3-yl)methanone

HRID 82208Notes

Reaction equation

HRID 82208 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([CH:19]([CH3:21])[CH3:20])[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[CH3:22][NH2:23]>>[CH:19]([N:12]1[C:13]2[N:14]=[CH:15][N:16]=[CH:17][C:18]=2[C:10]([C:8]([C:4]2[CH:5]=[N:6][CH:7]=[C:2]([NH:23][CH3:22])[CH:3]=2)=[O:9])=[CH:11]1)([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 70817675(5-Bromopyridin-3-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

Product 1

HCID 70817679(7-Isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(5-(methylamino)pyridin-3-yl)methanoneYield 13%

Procedure

The title compound was prepared according to the method described for Preparation 31 using (5-bromopyridin-3-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 94) and methylamine (20 mL) in 13% yield, 78 mg.

Sources & evidence

ORD record
ord-10e532021a2a44e69bc57fd8ba42bc0f
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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