Dichloromethane → 1-[5-(Trifluoromethyl)pyridin-2-yl]pyrrolidin-3-amine

HRID 822266Notes

Reaction equation

HRID 822266 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][N:10]([c:13]2[n:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]2)[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:23].[Cl:31][CH2:32][Cl:33].[OH:24][C:25]([C:26]([F:27])([F:28])[F:29])=[O:30]>>[NH2:7][CH:8]1[CH2:9][N:10]([c:13]2[n:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]2)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67001614Carbamic acid, N-[1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester

Product 1

HCID 185417401-[5-(Trifluoromethyl)pyridin-2-yl]pyrrolidin-3-amine

Sources & evidence

ORD record
ord-73492162bd38427bbe499b99a712c69e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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