Ethanol → Methyl 5-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-2-chlorobenzoate

HRID 822644Notes

Reaction equation

HRID 822644 reaction equation
[CH3:33][CH2:34][OH:35].[CH3:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1.[CH3:49][CH2:50][O:51][C:52](=[O:53])[CH3:54].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][c:9]([B:12]2[O:13][C:14]([CH3:15])([CH3:16])[C:17]([CH3:18])([CH3:19])[O:20]2)[cH:10][cH:11]1.[NH2:21][c:22]1[c:23]([C:29](=[O:30])[NH:31][CH3:32])[n:24][c:25]([Br:28])[cH:26][n:27]1.[Na+:36].[Na+:37].[O-:38][C:39](=[O:40])[O-:41]>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][c:9](-[c:25]2[n:24][c:23]([C:29](=[O:30])[NH:31][CH3:32])[c:22]([NH2:21])[n:27][cH:26]2)[cH:10][cH:11]1

Participants

8

Reactant 7

HCID 702EthanolHCID 923Sodium ion2×HCID 1140TolueneHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 151481213-Amino-6-bromo-N-methylpyrazine-2-carboxamideHCID 56972886Benzoic acid, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester

Product 1

HCID 68651344Methyl 5-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-2-chlorobenzoate

Sources & evidence

ORD record
ord-55e3933129f74bea96775fdcb22dbbfc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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