反应详情

温度

130 °C

Copper(I) oxide (38.6 mg, 0.27 mmol) was added to (5-Bromo-6-ethoxy-pyridin3-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone (Preparation 241, 350 mg, 0.89 mmol) in concentrated ammonia solution (6 mL) and NMP (1 mL). The mixture was heated in a sealed vessel at 130° C. for 17 hours. The reaction mixture was cooled to room temperature and diluted with water (10 ml). It was extracted with 20% i-PrOH in DCM (6×50 mL), dried (Na2SO4) and evaporated in vacuo. The crude material was purified by column chromatography on silica gel (MeOH:DCM 5:95) to afford the title compound as a yellow solid in 24% yield, 70 mg. LCMS (system 10): Rt=2.99 min; m/z 326 [M+H]+.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionIt was extracted with 20% i-PrOH in DCM (6×50 mL)
3. dry with materialdried (Na2SO4)
4. customevaporated in vacuo
5. customThe crude material was purified by column chromatography on silica gel (MeOH:DCM 5:95)