反应详情

A solution of 2-quinolin-4-yl-1-(3-trifluoromethyl-phenyl)-ethanone (1.0 g, 3.2 mmol) in ethanol (13 mL) is cooled to 0° C. and treated with hydrazine (0.6 g, 19 mmol) and concentrated hydrochloric acid (0.13 mL, 1.6 mmol). The mixture is refluxed for 2 h and concentrated in vacuo. The residue is taken up in dichloromethane and washed with saturated sodium bicarbonate (30 mL), water (2×30 mL), and brine (30 mL). The solution is dried over anhydrous sodium sulfate and filtered. The filtrate is concentrated to yield the title compound, 1.0 g (97%), as a pale yellow foam.

1. temperatureThe mixture is refluxed for 2 h
2. concentrationconcentrated in vacuo
3. washwashed with saturated sodium bicarbonate (30 mL), water (2×30 mL), and brine (30 mL)
4. dry with materialThe solution is dried over anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationThe filtrate is concentrated