5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide → HCID 86672126, compound

HRID 82282Notes

Reaction equation

HRID 82282 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10](I)=[CH:9][N:8]([C:12]([CH3:17])([CH3:16])[CH2:13][O:14][CH3:15])[C:6]=2[N:7]=1.[Br:18][C:19]1[CH:20]=[N:21][CH:22]=[C:23]([CH:30]=1)[C:24](N(OC)C)=[O:25]>>[Br:18][C:19]1[CH:30]=[C:23]([C:24]([C:10]2[C:5]3[CH:4]=[N:3][C:2]([Cl:1])=[N:7][C:6]=3[N:8]([C:12]([CH3:17])([CH3:16])[CH2:13][O:14][CH3:15])[CH:9]=2)=[O:25])[CH:22]=[N:21][CH:20]=1

Participants

3

Reactant 2

HCID 184722695-Bromo-N-methoxy-N-methylpyridine-3-carboxamideHCID 866721272-Chloro-5-iodo-7-(2-methoxy-1,1-dimethyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 86672126HCID 86672126, compound

Procedure

The title compound was prepared according to the method described for Preparation 64 using 2-Chloro-5-iodo-7-(2-methoxy-1,1-dimethyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine (Preparation 259) and 5-Bromo-N-methoxy-N-methyl-nicotinamide to afford the title compound as yellow gum in 34% yield, 900 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5c84d76bd7d5413e9deedb1ad3b31d94
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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