Acetate → 1-tert-Butyl 6-methyl 3-phenyl-1H-indole-1,6-dicarboxylate

HRID 823031Notes

Reaction equation

HRID 823031 reaction equation
[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[I:1][c:2]1[cH:3][n:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[c:5]2[cH:6][c:7]([C:11](=[O:12])[O:13][CH3:14])[cH:8][cH:9][c:10]12.[K+:36].[K+:37].[K+:38].[O-:47][C:48]([CH3:49])=[O:50].[O-:51][C:52]([CH3:53])=[O:54].[OH:22][B:23]([OH:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[P:31]([O-:32])([O-:33])([O-:34])=[O:35].[Pd+2:46]>>[c:2]1(-[c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[cH:3][n:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[c:5]2[cH:6][c:7]([C:11](=[O:12])[O:13][CH3:14])[cH:8][cH:9][c:10]12

Participants

8

Reactant 7

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 1061PhosphateHCID 1140TolueneHCID 66827Phenylboronic AcidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 71278271-tert-butyl 6-methyl 3-iodo-1H-indole-1,6-dicarboxylate

Product 1

HCID 596260441-tert-Butyl 6-methyl 3-phenyl-1H-indole-1,6-dicarboxylate

Sources & evidence

ORD record
ord-396df8f5624b4b11871828d36455f4da
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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