[3-(Hydroxymethyl)phenyl]boronic acid → (3-{2-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-methanol

HRID 823091Notes

Reaction equation

HRID 823091 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([NH:11][c:12]3[cH:13][cH:14][c:15]([N:18]4[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]4)[cH:16][cH:17]3)[n:9][n:10]12.[OH:25][CH2:26][c:27]1[cH:28][c:29]([B:33]([OH:34])[OH:35])[cH:30][cH:31][cH:32]1>>[c:2]1(-[c:29]2[cH:28][c:27]([CH2:26][OH:25])[cH:32][cH:31][cH:30]2)[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([NH:11][c:12]3[cH:13][cH:14][c:15]([N:18]4[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]4)[cH:16][cH:17]3)[n:9][n:10]12

Participants

3

Reactant 2

HCID 2734662[3-(Hydroxymethyl)phenyl]boronic acidHCID 66711200(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

Product 1

HCID 66711788(3-{2-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-methanol

Sources & evidence

ORD record
ord-cb214cdf06aa47e7b4809b2428dcc5ec
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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