Dichloromethane → 2-(3-Fluoro-5-(piperidin-4-ylidenemethyl)phenoxy)-5-(trifluoromethyl)pyridine
Reaction equation
[Cl:40][CH2:41][Cl:42].[F:1][c:2]1[cH:3][c:4]([CH:5]=[C:6]2[CH2:7][CH2:8][N:9]([C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[CH2:10][CH2:11]2)[cH:19][c:20]([O:22][c:23]2[n:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:21]1.[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[F:1][c:2]1[cH:3][c:4]([CH:5]=[C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]2)[cH:19][c:20]([O:22][c:23]2[n:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:21]1Participants
4
Sources & evidence
- ORD record
- ord-61f7f3eb36314e6b91daacd9fa957f59
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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