Hydrochloric Acid → HCID 67339039, compound

HRID 82354Notes

Reaction equation

HRID 82354 reaction equation
[CH3:1][C@@H:2]1[N:7]([C:8]2[C:9]3[C@H:16]([CH3:17])[CH2:15][CH2:14][C:10]=3[N:11]=[CH:12][N:13]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:25]>C(Cl)Cl>[ClH:25].[ClH:25].[CH3:17][C@H:16]1[C:9]2[C:8]([N:7]3[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]3[CH3:1])=[N:13][CH:12]=[N:11][C:10]=2[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58458250HCID 58458250, compound

Product 1

HCID 67339039HCID 67339039, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-tert-butyl 3-methyl-4-((R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate was treated with HCl (4M in dioxane, 4 mL) in DCM (20 mL) for 6 hours to provide the (R)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine dihydrochloride (0.18 g, 99%). MS (APCI+) [M+H]+233.

Sources & evidence

ORD record
ord-3031a0261430468bad71d111bb2f930a
Source dataset
uspto-grants-2014_09
Patent number
US08846681B2

Reaction notes

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