Dichloromethane → N-(3,5-Bis-trifluoromethyl-benzyl)-N-(7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-acetamide

HRID 823597Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[c:9]2[c:10]([cH:34][c:35]([C:38]([F:39])([F:40])[F:41])[cH:36][cH:37]2)[CH:11]([N:15]([CH2:16][c:17]2[cH:18][c:19]([C:27]([F:28])([F:29])[F:30])[cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[C:31]([CH3:32])=[O:33])[CH2:12][CH2:13][CH2:14]1)([CH3:5])([CH3:6])[CH3:7].[Cl:49][CH2:50][Cl:51].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48]>>[NH:8]1[c:9]2[c:10]([cH:34][c:35]([C:38]([F:39])([F:40])[F:41])[cH:36][cH:37]2)[CH:11]([N:15]([CH2:16][c:17]2[cH:18][c:19]([C:27]([F:28])([F:29])[F:30])[cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[C:31]([CH3:32])=[O:33])[CH2:12][CH2:13][CH2:14]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 590030995-[Acetyl-(3,5-bis-trifluoromethyl-benzyl)-amino]-7-trifluoromethyl-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86616072N-(3,5-Bis-trifluoromethyl-benzyl)-N-(7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-acetamide

Sources & evidence

ORD record: ord-db56b2308057490880946f1fedb277e7
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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