Hydrochloric Acid → 2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine

HRID 823720Notes

Reaction equation

HRID 823720 reaction equation
[C:2]([O:3][C:4](=[O:5])[NH:8][CH2:9][c:10]1[c:11]([Cl:39])[c:12]([NH:17][c:18]2[n:19][c:20]3[c:21]([n:22]2[CH3:23])[cH:24][c:25]([N:29]2[CH2:30][CH:31]([C:35]([F:36])([F:37])[F:38])[CH2:32][CH2:33][CH2:34]2)[c:26]([Cl:28])[cH:27]3)[c:13]([Cl:16])[cH:14][cH:15]1)([CH3:6])([CH3:7])[CH3:40].[ClH:1].[O:41]1[CH2:42][CH2:43][O:44][CH2:45][CH2:46]1>>[NH2:8][CH2:9][c:10]1[c:11]([Cl:39])[c:12]([NH:17][c:18]2[n:19][c:20]3[c:21]([n:22]2[CH3:23])[cH:24][c:25]([N:29]2[CH2:30][CH:31]([C:35]([F:36])([F:37])[F:38])[CH2:32][CH2:33][CH2:34]2)[c:26]([Cl:28])[cH:27]3)[c:13]([Cl:16])[cH:14][cH:15]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86674334N-{2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzyl}-carbamic acid tert-butyl ester

Product 1

HCID 866743352,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine

Sources & evidence

ORD record
ord-eb48c7b339034383ac7732811cfa7d3e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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