反应详情

To a solution of 2-pyridin-2-yl-3-quinolin-4-yl-pyrazolo[5,1-c]morpholin-4-one (0.50 g, 1.46 mmol) in tetrahydrofuran (20 mL) is added LiAlH4 (0.50 g, 13.1 mmol) at room temperature. The mixture is stirred for 2 h quenched with 1 N sodium hydroxide solution, and partitioned between dichloromethane and water. The organic portion is dried (sodium sulfate), filtered, and concentrated in vacuo. The residue is chromatographed on SiO2 (10% methanol/dichloromethane) to yield the title compound, 0.35 g (70%), as an off-white solid.

1. customquenched with 1 N sodium hydroxide solution
2. custompartitioned between dichloromethane and water
3. dry with materialThe organic portion is dried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue is chromatographed on SiO2 (10% methanol/dichloromethane)