Bicarbonate Ion → 1-Chloro-4-(2-methylpiperazin-1-yl)phthalazine

HRID 824210Notes

Reaction equation

HRID 824210 reaction equation
[Cl:1][c:2]1[n:3][n:4][c:5]([N:12]2[CH:13]([CH3:25])[CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[Cl:38][CH2:39][Cl:40].[Na+:37].[O-:33][C:34]([OH:35])=[O:36].[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[Cl:1][c:2]1[n:3][n:4][c:5]([N:12]2[CH:13]([CH3:25])[CH2:14][NH:15][CH2:16][CH2:17]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 76610677Tert-butyl 4-(4-chlorophthalazin-1-yl)-3-methylpiperazine-1-carboxylate

Product 1

HCID 766106781-Chloro-4-(2-methylpiperazin-1-yl)phthalazine

Sources & evidence

ORD record
ord-cf12e2960f7247b5bcdf6ded855d57cd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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