Ethanol → 2-(2,6-Difluorophenyl)-1-[(2,6-difluorophenyl)methyl]benzimidazole-4-carboxamide

HRID 824949Notes

Reaction equation

HRID 824949 reaction equation
[C:29]([O-:30])(=[O:31])[O-:32].[CH3:37][CH2:38][OH:39].[F:1][c:2]1[c:3]([CH2:4][n:5]2[c:6](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[n:7][c:8]3[c:9]2[cH:10][cH:11][cH:12][c:13]3[C:14]#[N:15])[c:24]([F:28])[cH:25][cH:26][cH:27]1.[Na+:33].[Na+:34].[OH:35][OH:36]>>[F:1][c:2]1[c:3]([CH2:4][n:5]2[c:6](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[n:7][c:8]3[c:9]2[cH:10][cH:11][cH:12][c:13]3[C:14]([NH2:15])=[O:30])[c:24]([F:28])[cH:25][cH:26][cH:27]1

Participants

6

Reactant 5

HCID 702EthanolHCID 784Hydrogen PeroxideHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 98647011-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)benzimidazole-4-carbonitrile

Product 1

HCID 4926802-(2,6-Difluorophenyl)-1-[(2,6-difluorophenyl)methyl]benzimidazole-4-carboxamide

Sources & evidence

ORD record
ord-7242408ccbf942f1be2acbd8071926c5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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