Dimethylamine → 5-(Dimethylamino)pyridin-3-OL

HRID 825181Notes

Reaction equation

HRID 825181 reaction equation
[CH2:14]1[O:15][CH2:16][CH2:17][CH2:18]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:6]1[O:7][CH2:8][CH2:9][CH2:10]1.[CH3:11][NH:12][CH3:13].[CH3:27][CH2:28][OH:29].[Cl:19][c:20]1[cH:21][n:22][cH:23][c:24]([OH:26])[cH:25]1>>[CH3:11][N:12]([CH3:13])[c:20]1[cH:21][n:22][cH:23][c:24]([OH:26])[cH:25]1

Participants

6

Reactant 5

HCID 674DimethylamineHCID 702EthanolHCID 8028Tetrahydrofuran2×HCID 5823053-Hydroxy-5-chloropyridineHCID 178418339Butyllithium

Product 1

HCID 574218155-(Dimethylamino)pyridin-3-OL

Sources & evidence

ORD record
ord-706186cdad15423cb77f8661fd8fdf45
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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