Hydrochloric Acid → Methyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-2-carboxylate

HRID 825483Notes

Reaction equation

HRID 825483 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([C:9]([C:10]([F:11])([F:12])[F:13])([C:14]([F:15])([F:16])[F:17])[OH:18])[cH:7][cH:8]1.[C:19](=[O:20])([O-:21])[O-:22].[CH3:37][C:38]#[N:39].[ClH:25].[ClH:26].[K+:23].[K+:24].[NH:27]1[CH:28]([C:33](=[O:34])[O:35][CH3:36])[CH2:29][NH:30][CH2:31][CH2:32]1>>[CH2:2]([c:3]1[cH:4][cH:5][c:6]([C:9]([C:10]([F:11])([F:12])[F:13])([C:14]([F:15])([F:16])[F:17])[OH:18])[cH:7][cH:8]1)[N:30]1[CH2:29][CH:28]([C:33](=[O:34])[O:35][CH3:36])[NH:27][CH2:32][CH2:31]1

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 2760426Methyl Piperazine-2-carboxylateHCID 235273962-[4-(Bromomethyl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Product 1

HCID 86638569Methyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-2-carboxylate

Sources & evidence

ORD record
ord-86ff8e28f847478998ed24da458369e0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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