反应详情

温度

60 °C

To a solution of 4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline-7-carboxylic acid ethyl ester (250 mg, 0.6 mmol) in methanol (4 mL) at room temperature is added 1 N lithium hydroxide (1.2 mL, 1.2 mmol). The mixture is heated at 60° C. for 4 h. The mixture is cooled to room temperature and concentrated in vacuo. The mixture is diluted with water and acidified to pH 6 with 1 N hydrochloric acid. The aqueous solution is extracted with dichloromethane 5 times. The combined organic extracts are dried (sodium sulfate), filtered, and concentrated in vacuo to yield the title compound, 150 mg (65%), as an off white solid.

1. temperatureThe mixture is cooled to room temperature
2. concentrationconcentrated in vacuo
3. additionThe mixture is diluted with water
4. extractionThe aqueous solution is extracted with dichloromethane 5 times
5. dry with materialThe combined organic extracts are dried (sodium sulfate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo