反应详情

温度

0 °C

2-(Methylthio)-3H-imidazo[4,5-b]pyridine (3.5 g) was dissolved in conc. HCl (10 mL), and then the mixture was cooled to 0° C. Chlorine gas was bubbled through the mixture for 2 h in iced bath. The mixture was poured onto ice, and neutralized to pH 7 with aqueous ammonium solution. The precipitate was collected by filtration to give the title compound as white crystals (1.0 g).

1. customChlorine gas was bubbled through the mixture for 2 h in iced bath
2. additionThe mixture was poured onto ice
3. filtrationThe precipitate was collected by filtration