Hydroxide → tert-butyl 6-(6-(6-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

HRID 825685Notes

Reaction equation

[C:1](=[O:2])([CH3:3])[O:4][CH2:5][c:6]1[c:7](-[c:28]2[cH:29][c:30]([NH:36][c:37]3[cH:38][cH:39][c:40]([N:43]4[CH2:44][C:45]5([CH2:46][N:47]([C:49](=[O:50])[O:51][C:52]([CH3:53])([CH3:54])[CH3:55])[CH2:48]5)[CH2:56]4)[cH:41][n:42]3)[c:31](=[O:35])[n:32]([CH3:34])[n:33]2)[cH:8][cH:9][cH:10][c:11]1-[n:12]1[c:13](=[O:27])[c:14]2[c:15]([F:26])[cH:16][c:17]([C:22]([CH3:23])([CH3:24])[CH3:25])[cH:18][c:19]2[cH:20][n:21]1.[Li+:58].[O:59]1[CH2:60][CH2:61][O:62][CH2:63][CH2:64]1.[OH-:57]>>[OH:4][CH2:5][c:6]1[c:7](-[c:28]2[cH:29][c:30]([NH:36][c:37]3[cH:38][cH:39][c:40]([N:43]4[CH2:44][C:45]5([CH2:46][N:47]([C:49](=[O:50])[O:51][C:52]([CH3:53])([CH3:54])[CH3:55])[CH2:48]5)[CH2:56]4)[cH:41][n:42]3)[c:31](=[O:35])[n:32]([CH3:34])[n:33]2)[cH:8][cH:9][cH:10][c:11]1-[n:12]1[c:13](=[O:27])[c:14]2[c:15]([F:26])[cH:16][c:17]([C:22]([CH3:23])([CH3:24])[CH3:25])[cH:18][c:19]2[cH:20][n:21]1