Tetrahydrofuran → 4-[tert-butyl(dimethyl)silyl]oxy-N-(3-chloro-4-cyano-2-methylphenyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide
Reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[Cl:1][c:2]1[c:3]([CH3:30])[c:4]([NH:10][C:11](=[O:12])[N:13]2[CH:14]([C:26](=[O:27])[O:28][CH3:29])[CH2:15][CH:16]([O:18][Si:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17]2)[cH:5][cH:6][c:7]1[C:8]#[N:9]>>[Cl:1][c:2]1[c:3]([CH3:30])[c:4]([NH:10][C:11](=[O:12])[N:13]2[CH:14]([CH2:26][OH:27])[CH2:15][CH:16]([O:18][Si:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17]2)[cH:5][cH:6][c:7]1[C:8]#[N:9]Participants
3
Sources & evidence
- ORD record
- ord-299b705aa0954d88a785cda9318fe02d
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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