Acetone → 8-methoxycarbonyl-4,4-dimethyl-4H-pyrrolo[2,1-c][1,4]-benzoxazine

HRID 825814Notes

Reaction equation

HRID 825814 reaction equation
[CH3:17][C:18]([CH3:19])=[O:20].[CH3:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[OH:1][c:2]1[c:3](-[n:12]2[cH:13][cH:14][cH:15][cH:16]2)[cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1.[c:21]1([CH3:22])[cH:23][cH:24][c:25]([S:26]([OH:27])(=[O:28])=[O:29])[cH:30][cH:31]1>>[O:1]1[c:2]2[c:3]([cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]2)-[n:12]2[c:13]([cH:14][cH:15][cH:16]2)[C:18]1([CH3:17])[CH3:19]

Participants

5

Reactant 4

HCID 180AcetoneHCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 18945287Methyl 4-hydroxy-3-(pyrrol-1-yl)benzoate

Product 1

HCID 189453208-methoxycarbonyl-4,4-dimethyl-4H-pyrrolo[2,1-c][1,4]-benzoxazine

Sources & evidence

ORD record
ord-fe29fb2d0de841f980f2e21f985a12eb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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