反应详情

To a solution of 1H-imidazo[4,5-c]pyridine-2-thiol (4 g) in acetone (50 mL) were added potassium carbonate (11 g) and MeI (1.8 ml). After stirring for 3 h, the mixture was filtered. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluted with 10%-70% EtOAc in hexane) to give 2-(methylsulfanyl)-1H-imidazo[4,5-c]pyridine (4.07 g) as a yellow solid.

1. filtrationthe mixture was filtered
2. concentrationThe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography (silica gel, eluted with 10%-70% EtOAc in hexane)