1,2-Dichloroethane → 2-{5-[1-(3-Fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-4'-trifluoromethyl-biphenyl-3-yl}-4-methyl-pentanoic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([CH2:6][CH:7]([CH3:8])[CH3:9])[c:10]1[cH:11][c:12](-[c:22]2[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2)[cH:13][c:14]([CH:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[cH:15]1)=[O:32].[Cl:46][CH2:47][CH2:48][Cl:49].[F:33][c:34]1[cH:35][c:36]([CH:37]=[O:38])[cH:39][c:40]([C:42]([F:43])([F:44])[F:45])[cH:41]1>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([CH2:6][CH:7]([CH3:8])[CH3:9])[c:10]1[cH:11][c:12](-[c:22]2[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2)[cH:13][c:14]([CH:16]2[CH2:17][CH2:18][N:19]([CH2:37][c:36]3[cH:35][c:34]([F:33])[cH:41][c:40]([C:42]([F:43])([F:44])[F:45])[cH:39]3)[CH2:20][CH2:21]2)[cH:15]1)=[O:32]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e432913fe9c34f16ac83af622aba40a6
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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