Imidazole → 2-Amino-3-(tert-butyldimethylsilanyloxy)-1-phenylpropan-1-ol

HRID 826503Notes

Reaction equation

HRID 826503 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[Si:22]([CH3:23])([CH3:24])[Cl:25].[NH2:1][CH:2]([CH:3]([OH:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[CH2:11][OH:12].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[nH:13]1[cH:14][cH:15][n:16][cH:17]1>>[NH2:1][CH:2]([CH:3]([OH:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[CH2:11][O:12][Si:22]([C:18]([CH3:19])([CH3:20])[CH3:21])([CH3:23])[CH3:24]

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 1029712-Amino-1-phenyl-1,3-propanediol

Product 1

HCID 147318252-Amino-3-(tert-butyldimethylsilanyloxy)-1-phenylpropan-1-ol

Sources & evidence

ORD record
ord-fa83cb58dd0c49a6a3fb0f2c83d9ed2c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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