Dimethyl Sulfoxide → 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol

HRID 826759Notes

Reaction equation

HRID 826759 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH3:27][S:28]([CH3:29])=[O:30].[F:7][c:8]1[cH:9][c:10]([O:17][CH3:18])[c:11]([N+:14](=[O:15])[O-:16])[cH:12][cH:13]1.[K+:5].[K+:6].[NH:19]1[CH2:20][CH2:21][CH:22]([OH:25])[CH2:23][CH2:24]1.[OH2:26]>>[c:8]1([N:19]2[CH2:20][CH2:21][CH:22]([OH:25])[CH2:23][CH2:24]2)[cH:9][c:10]([O:17][CH3:18])[c:11]([N+:14](=[O:15])[O-:16])[cH:12][cH:13]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 79341Piperidin-4-olHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 259188601-(3-Methoxy-4-nitrophenyl)piperidin-4-ol

Sources & evidence

ORD record
ord-2f56cd244d7841eba42b657b69fab22a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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