4-Isopropylaniline → 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine

HRID 826989Notes

Reaction equation

HRID 826989 reaction equation
[CH:17]([CH3:18])([CH3:19])[c:20]1[cH:21][cH:22][c:23]([NH2:24])[cH:25][cH:26]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:24][c:23]2[cH:22][cH:21][c:20]([CH:17]([CH3:18])[CH3:19])[cH:26][cH:25]2)[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 74644-IsopropylanilineHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

Product 1

HCID 220607815-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-b9abacea164245c0adc0ba9b16938a5c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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