Sodium ion → 3-(5-Cyclopropyl-2,4-dimethyl-phenyl)-4-hydroxy-8-methoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

HRID 827071Notes

Reaction equation

HRID 827071 reaction equation
[CH3:1][O-:2].[CH3:32][N:33]([CH3:34])[CH:35]=[O:36].[CH3:4][O:5][C:6](=[O:7])[C:8]1([NH:16][C:17]([CH2:18][c:19]2[c:20]([CH3:29])[cH:21][c:22]([CH3:28])[c:23]([CH:25]3[CH2:26][CH2:27]3)[cH:24]2)=[O:30])[CH2:9][CH2:10][N:11]([O:14][CH3:15])[CH2:12][CH2:13]1.[Na+:3].[OH2:31]>>[C:6]1([OH:7])=[C:18]([c:19]2[c:20]([CH3:29])[cH:21][c:22]([CH3:28])[c:23]([CH:25]3[CH2:26][CH2:27]3)[cH:24]2)[C:17](=[O:30])[NH:16][C:8]12[CH2:9][CH2:10][N:11]([O:14][CH3:15])[CH2:12][CH2:13]2

Participants

6

Reactant 5

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 3826051MethoxideHCID 596145774-[2-(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetylamino]-1-methoxy-piperidine-4-carboxylic acid methyl ester

Product 1

HCID 596145913-(5-Cyclopropyl-2,4-dimethyl-phenyl)-4-hydroxy-8-methoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

Sources & evidence

ORD record
ord-1b47925e623845ce8fc79f2877b55e74
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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