Dichloromethane → 4-(2-Amino-2-cyclohexyl-acetyl)-1-methanesulfonyl-octahydro-pyrrolo[3,2-b]pyrrole-3-carboxylic acid (1-phenyl-ethyl)-amide

HRID 827084Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]([C:9](=[O:10])[N:11]1[CH:12]2[CH:13]([CH2:14][CH2:15]1)[N:16]([S:30](=[O:31])(=[O:32])[CH3:33])[CH2:17][CH:18]2[C:19]([NH:20][CH:21]([CH3:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:29])[CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)([CH3:5])([CH3:6])[CH3:40].[Cl:48][CH2:49][Cl:50].[F:41][C:42]([F:43])([F:44])[C:45]([OH:46])=[O:47]>>[NH2:7][CH:8]([C:9](=[O:10])[N:11]1[CH:12]2[CH:13]([CH2:14][CH2:15]1)[N:16]([S:30](=[O:31])(=[O:32])[CH3:33])[CH2:17][CH:18]2[C:19]([NH:20][CH:21]([CH3:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:29])[CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 67282347{1-Cyclohexyl-2-[4-methanesulfonyl-6-(1-phenyl-ethylcarbamoyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 672815224-(2-Amino-2-cyclohexyl-acetyl)-1-methanesulfonyl-octahydro-pyrrolo[3,2-b]pyrrole-3-carboxylic acid (1-phenyl-ethyl)-amide

Sources & evidence

ORD record: ord-8f53120bfc1f4a71847c760eccfeeb7d
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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