Pyridine → 3-(4-ethylphenyl)-7-(4-fluoroanilino)-1-(1-hydroxypropan-2-yl)-4H-pyrimido[4,5-d]pyrimidin-2-one
Reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH:8]([CH3:9])[N:10]1[C:11](=[O:36])[N:12]([c:28]2[cH:29][cH:30][c:31]([CH2:34][CH3:35])[cH:32][cH:33]2)[CH2:13][c:14]2[c:15]1[n:16][c:17]([NH:20][c:21]1[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]1)[n:18][cH:19]2)([CH3:5])([CH3:37])[CH3:38].[FH:45].[cH:46]1[cH:47][cH:48][n:49][cH:50][cH:51]1.[n:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[OH:6][CH2:7][CH:8]([CH3:9])[N:10]1[C:11](=[O:36])[N:12]([c:28]2[cH:29][cH:30][c:31]([CH2:34][CH3:35])[cH:32][cH:33]2)[CH2:13][c:14]2[c:15]1[n:16][c:17]([NH:20][c:21]1[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]1)[n:18][cH:19]2Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-4685e9dca62245888ad0a5613be09e13
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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