Sodium ion → 5-bromo-3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine

HRID 827400Notes

Reaction equation

HRID 827400 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[cH:9][c:10]2[I:11].[CH3:20][O:21][c:22]1[c:23]([B:28]([OH:29])[OH:30])[cH:24][cH:25][cH:26][cH:27]1.[CH3:31][C:32]#[N:33].[Na+:34].[Na+:35].[O-:36][C:37](=[O:38])[O-:39].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[cH:9][c:10]2-[c:23]1[c:22]([O:21][CH3:20])[cH:27][cH:26][cH:25][cH:24]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 27339582-Methoxyphenylboronic acidHCID 592970265-bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 592970285-bromo-3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine

Sources & evidence

ORD record
ord-d152c1f0451c41e59082cc81f199debe
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…