Dichloromethane → Thiazole, 5-(chloromethyl)-2-[4-(trifluoromethyl)phenyl]-

HRID 827506Notes

Reaction equation

HRID 827506 reaction equation
[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:25][S:26]([Cl:27])(=[O:28])=[O:29].[Cl:30][CH2:31][Cl:32].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[s:10][c:11]([CH2:14][OH:15])[cH:12][n:13]2)[cH:7][cH:8]1)([F:16])[F:17]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[s:10][c:11]([CH2:14][Cl:27])[cH:12][n:13]2)[cH:7][cH:8]1)([F:16])[F:17]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 22647407{2-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol

Product 1

HCID 22647608Thiazole, 5-(chloromethyl)-2-[4-(trifluoromethyl)phenyl]-

Sources & evidence

ORD record
ord-34634230b88145b48050c8ced5daf279
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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