反应详情

温度

40 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (5-((4-nitro-2H-1,2,3-triazol-2-yl)methyl)furan-2-yl)methanol (WO 2009077990A1) (186 mg, 0.83 mmol) in CH2Cl2 (3.0 mL) was added to a suspension of Ag2O (288 mg, 1.24 mmol) and MeI (0.06 mL, 0.99 mmol). The resulting mixture (protected form light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (7:3 hept-EA) gave the title compound as a yellow oil: TLC: rf (7:3 hept-EA)=0.27. LC-MS-conditions 07: tR=0.74 min.

1. filtrationThe reaction mixture was filtered
2. customthe solvent was removed under reduced pressure
3. customPurification of the residue by FC (7:3 hept-EA)