反应详情

温度

40 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (4-((4-nitro-2H-1,2,3-triazol-2-yl)methyl)thiazol-2-yl)methanol (419 mg, 1.74 mmol) in CH2Cl2 (15.0 mL) was added to a suspension of Ag2O (604 mg, 2.61 mmol) and MeI (0.33 mL, 5.21 mmol). The resulting mixture (protected form light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (1:1 hept-EA) gave the title compound as a yellow oil. TLC: rf (1:1 hept-EA)=0.36. LC-MS-conditions 07: tR=0.68 min, [M+H]+=256.27.

1. filtrationThe reaction mixture was filtered
2. customthe solvent was removed under reduced pressure
3. customPurification of the residue by FC (1:1 hept-EA)