Methyl iodide → 1-(tert-Butyl-dimethyl-silanyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine

HRID 828319Notes

Reaction equation

HRID 828319 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([Si:11]([CH3:12])([CH3:13])[C:14]([CH3:15])([CH3:16])[CH3:17])[cH:9][cH:10]2.[CH2:18]([Li:19])[CH2:20][CH2:21][CH3:22].[CH3:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].[CH3:29][I:30].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[c:2]1([CH3:18])[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([Si:11]([CH3:12])([CH3:13])[C:14]([CH3:15])([CH3:16])[CH3:17])[cH:9][cH:10]2

Participants

6

Reactant 5

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 497590181H-Pyrrolo[2,3-B]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-HCID 178418339Butyllithium

Product 1

HCID 575978501-(tert-Butyl-dimethyl-silanyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine

Sources & evidence

ORD record
ord-2613165022754a018077c1877992e135
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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