8-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one → {2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-phenoxy]-acetonitrile

HRID 828588Notes

Reaction equation

HRID 828588 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:11][CH2:12][C:13]#[N:14])[cH:15][cH:16][cH:17][c:18]2[F:19])[n:7]1.[NH2:21][c:22]1[cH:23][cH:24][c:25]2[c:26]([cH:35]1)[NH:27][C:28](=[O:34])[CH2:29][CH2:30][C:31]2([CH3:32])[CH3:33]>>[c:2]1([NH:21][c:22]2[cH:23][cH:24][c:25]3[c:26]([cH:35]2)[NH:27][C:28](=[O:34])[CH2:29][CH2:30][C:31]3([CH3:32])[CH3:33])[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:11][CH2:12][C:13]#[N:14])[cH:15][cH:16][cH:17][c:18]2[F:19])[n:7]1

Participants

3

Reactant 2

HCID 574160628-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-oneHCID 86633948[2-(2,5-Dichloropyrimidin-4-ylamino)-3-fluorophenoxy]-acetonitrile

Product 1

HCID 66830311{2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-phenoxy]-acetonitrile

Sources & evidence

ORD record
ord-c69b00002bfb449d8c074b745afb1d0b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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