Sodium ion → 4-(4-Acryloylpiperazin-1-yl)-2-fluorobenzonitrile

HRID 828722Notes

Reaction equation

HRID 828722 reaction equation
[C:23]([CH:24]=[CH2:25])(=[O:26])[Cl:27].[C:28](=[O:29])([O-:30])[O-:31].[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[Cl:34][CH2:35][Cl:36].[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[cH:9]1.[Na+:32].[Na+:33]>>[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([N:10]2[CH2:11][CH2:12][N:13]([C:23]([CH:24]=[CH2:25])=[O:26])[CH2:14][CH2:15]2)[cH:9]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 19660Carbonate IonHCID 187600452-Fluoro-4-(piperazin-1-YL)benzonitrile

Product 1

HCID 684518974-(4-Acryloylpiperazin-1-yl)-2-fluorobenzonitrile

Sources & evidence

ORD record
ord-75502f25ca9443dda3d6f494d205f73f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…