反应详情

To a solution of ethyl 1-benzyl-1-hydroxy-6-methoxy-2,3-dihydro-1H-inden-2-ylcarbamate (184 mg, 0.539 mmol) in toluene (4 ml) was added methanesulfonic acid (3.50 μl, 0.054 mmol) and stirred at room temperature over night. The solution was evaporated, re-dissolved in dichloromethane, washed with sodium bicarbonate and brine, dried over sodium bicarbonate and evaporated to dryness to obtain the desired (Z)-ethyl 1-benzylidene-6-methoxy-2,3-dihydro-1H-inden-2-ylcarbamate as a pale yellow oil. m=154 mg (88%)

1. customThe solution was evaporated
2. dissolutionre-dissolved in dichloromethane
3. washwashed with sodium bicarbonate and brine
4. dry with materialdried over sodium bicarbonate
5. customevaporated to dryness